The structure of insecticidal toxins from Yersinia entomophaga

In collaboration with Mark Hurst, Biosecurity and Biocontrol

The insecticidal tc toxins produced by a number of bacteria form large (~2.5MDa) complexes, where the assembly of up to seven proteins are required to show full insecticidal activity. The general architecture of these complexes has previously been established using single-particle EM analysis, but the structural details of the complexes, and their mode of action, remain obscure. This project aims to elucidate the structures and functions of components of the tc toxin complex from the bacterium Yersinia entomophaga.